Saul was performed on May 25, and a second performance of Messiah took place on June 3. Handel left Ireland on August 13. In another letter to Jennens he says that his plans for the winter are undecided; for "this time twelve-month" (i.e. September 1743) he intended to continue his oratorios in Ireland. For some reason or other this second visit to Ireland never took place.

It was not until February 17, 1743, that Handel came before the London public again with Samson, which, unlike most of his oratorios, had an immediate success. He had by this time dropped the Italian singers altogether, and depended mainly on Mrs. Cibber and John Beard, a tenor who had more sense of artistic style than power of voice. Mr. Flower says that his voice was more powerful than sweet; Horace Walpole, who heard him, said that he had only one note in it, and Mrs. Pendarves, whose judgment was probably more trustworthy, said that he had no voice at all. The first London performance of Messiah was given on March 23, but it had no more than two subsequent repetitions this season. There were many reasons why it should have fallen flat. Jennens himself was extremely dissatisfied with it. Israel had been a failure too, and it is extremely probable that musical people, accustomed to the Italian opera, were estranged by a setting of Bible words in prose instead of a libretto in verse laid out on more or less dramatic lines.

William Law's Serious Call had been published in 1729; the book makes frequent allusions to the frivolity of Italian opera, and opera-going is picked out as one of the chief characteristics of irreligious persons. In 1739 John Wesley first began to preach in the open air; in 1742 Edward Young's Night Thoughts achieved its extraordinary popularity. These three events were all significant of the religious movement that was taking place among the more cultured classes in England, and this movement undoubtedly affected Handel's oratorio concerts. The ultra-religious were shocked at the association of sacred subjects with the theatre; those who could combine religion with culture, like Mrs. Delany, who was now approaching the age of piety, were Handel's most earnest supporters. It is quite probable that the section of society which preferred its culture unmixed with religion resented the attitude of the second party even more than that of the first, because the second party belonged to their own social class, and this resentment may well have contributed to the ever-increasing hostility shown by many social leaders toward Handel. And Handel's personal oddities were becoming rapidly more acute, partly owing to increasing age, and still more owing to recurrences of paralysis and associated mental derangement. He had another attack in this very year—1743.

Messiah and Samson were composed at a more favourable moment, and show little use of borrowed material, except that Messiah incorporates some of Handel's own chamber duets, the melodies of which were more suitably illustrative of their original Italian words than of the sentences from Scripture to which he adapted them. But his next important work, the Te Deum in celebration of the victory at Dettingen (June 27), begun in July and performed on November 27, incorporates no less than nine movements from the Latin Te Deum by Urio already drawn upon for Israel in Egypt. Mrs. Delany "was all raptures," and thought it "excessively fine."

It is curious that, whereas the Dettingen Te Deum was largely based on borrowed material, Semele, composed in the previous month of June, should be, as far as is at present known, entirely original. The libretto had been written by Congreve in 1707 for an opera, and it was only natural that its theatrical sense and its literary grace and distinction should have inspired Handel to one of his loveliest works. Handel was never quite at home in the English language, but in his later years he seems to have developed a feeling for English poetry, more especially for that of approximately his own time. But Semele did not attract the opera audience; it became increasingly clear that the opera party would have nothing to do with Handel, and were in fact deliberately doing all they could to bring him to ruin. Mrs. Delany and a few other great ladies remained faithful, but they were in a small minority. It was evidently the younger generation who were in opposition; Mrs. Delany alludes to them as "the Goths—the fine ladies, the petits maîtres and the ignoramuses," and seemed surprised that they allowed the oratorio to be performed without making a disturbance. Mrs. Delany was settling down to being the wife of a dean.

Joseph (March 2, 1744) fared no better, and Handel himself "was mightily out of humour about it" at the rehearsals. The summer was devoted to the composition of Belshazzar, for which Jennens had supplied the libretto. The collaboration was not altogether happy, for although Jennens had considerable sense of the picturesque, and offered Handel opportunities for what may be called spectacular music on the grand scale, his literary style was pompous, rhetorical, and long-winded. Handel protested perpetually against the length of the work, for the Handelian style of composition naturally extended the prolixity of the words; Jennens greatly resented the musician's criticism, and insisted on printing the poem in full.

When the winter came, Handel produced nothing of importance until January 5, when he brought out Hercules, a secular oratorio which he had composed in the summer during intervals when Belshazzar had to be laid aside owing to Jennens' delays. Belshazzar was given on March 27. Semele, Joseph, and Saul were revived, but, whatever oratorio was given, the theatre was almost empty, and the season came to a premature end on April 23. Handel was again suffering from some form of illness, and was unable to take any part in the performances, although he was present at them. Lady Shaftesbury describes "the great, though unhappy, Handel, dejected, wan and dark, sitting by, not playing on, the harpsichord," and adds that "his light had been spent in being overplied in music's cause." Hawkins states definitely that Handel became blind in 1751, and this date has been generally accepted; Lady Shaftesbury's letter suggests that he was already blind, or partially so, as early as March 1745, unless the word "light" is to be taken as meaning the light of his reason. This interpretation, in fact, is confirmed by a later letter of Lord Shaftesbury in October, in which he says: "Poor Handel looks something better. I hope he will entirely recover in due time, though he has been a good deal disordered in the head." Another friend of Handel's, William Harris, met him in London, in August, when he seems at first not to have recognised Harris and to have behaved with some oddity; "he talked much of his precarious state of health, yet he looks well enough."

It has generally been stated that in 1745 Handel again became bankrupt, but Barclay Squire pointed out that his name does not occur in the official lists of bankrupts. It must be remembered that, however disastrous his opera or oratorio seasons were, he had always his permanent pension of £600 a year to fall back on, and Hawkins states that this pension, originally granted by Queen Anne and George I, was punctually paid throughout his life.

From the end of August, London was in a panic over the Jacobite rebellion under the Young Pretender, Charles Edward. The Opera remained closed on account of the prejudice against the Papist Italian singers; at the other theatres patriotism expressed itself in appropriate music. Purcell's "Genius of England" was sung at one, Arne's recently composed "Rule, Britannia" at another, and on November 14 a "Chorus Song, set by Mr. Handel for the Gentlemen Volunteers of the City of London," was sung by Mr. Lowe at Drury Lane. The words suggest that the anonymous author was familiar with the Epilogue to Purcell's King Arthur; Handel's music is neither in his own style nor in Purcell's, but resembles the poorest sort of English patriotic song of the early eighteenth century. Patriotic poetry was well illustrated by an additional verse for "God Save the King" which was printed in this same month:

From France and Pretender
Great Britain defend her,
Foes let them fall;
From foreign slavery,
Priests and their knavery,
And Popish Reverie,
God save us all.